Amlodipine Gingival Hyperplasia
Case 3 — a intraoral picture at first visit b two months after phase-1 therapy. Histologic examination of the specimen demonstrated hyperkeratinized and proliferating stratified squamous epithelium. The amlodipine mechanism behind drug-induced gingival hyperplasia involves inflammatory and noninflammatory pathways. Figure 5. Drugs associated with gingival enlargement, their brand names, and estimated prevalence rates are summarized in Table 1. Clinically, the differential diagnosis for the localized growth included pyogenic granuloma, fibroma, and peripheral ossifying gingival. The importance of the microbial plaque as a cofactor in the etiology of drug-associated gingival enlargement has been recognized in a recent classification system of periodontal diseases by the American Academy of Periodontology. The patient in the case presented had gingival hyperplasia as hyperplasia result of managing his hypertension with amlodipine. Among the calcium channel blockers, gingival enlargement has most frequently been described as a side effect following administration of nifedipine. The 9-month follow-up visit is shown in [ Figure 2 c].
Amlodipine-induced Massive Gingival Hypertrophy
The prevalence with amlodipine, Limited amount of collagenase becomes available [ 8 ]. Despite the relatively high prevalence of nifedipine-induced gingival hyperplasia 3hyperplasia has rarely been reported as the potential etiologic cause of gingival hyperplasia 3,5,6. Cyclosporine enlargement usually have a more highly vascularized connective tissue with foci of chronic inflammatory cells, particularly plasma amlodipine, 20 plus presence of an abundant amorphous extracellular substance. J Periodontol. View at: Google Scholar Gingigal. The underlying mechanism behind drug-induced gingival hyperplasia involves inflammatory and noninflammatory pathways. However, a serious and often overlooked side effect of this class of drugs affects some patients. Calcium channel blocker-induced gingival enlargement. Fleckenstein A. J Indian Soc Periodontol ; Jorgensen MG. The attached gingiva was erythematous Fig. This class derives its main therapeutic effects by preventing calcium ion influx through the cell membranes. Open in a separate window. After this, incisional biopsy was done. Treatment of gingivao gingival enlargement The most effective treatment of these lesions is cessation of the offending medication and a substitution with another class, or a cocktail, of antihypertensive drugs by gingival medical provider. Shemesh, H. Calcium channel blockers and gingival overgrowth. Possible reason can be that individuals with gingival enlargement have fibroblasts with an abnormal susceptibility to the drug. A year old male patient reported to the Department of Oral Medicine and Radiology, with a chief complaint of swelling in the upper and lower gums for three months.
Case 3 — a intraoral picture at first visit b two months after phase-1 therapy. External link. Abstract Despite hyperplasia popularity and wide acceptance of the calcium channel blockers CCBs by the medical community, their oral impact is rarely recognized or discussed. Amlodipine other formats More. Thank you for visiting nature, amlodipine gingival hyperplasia. Med Clin Barc901 Sep He had received a renal transplant for focal segmental glomerulosclerosis in Treatment of gingival overgrowth induced by manidipine administration. Figure 1: Preoperative clinical photograph showing disfigurement of the gingiva in the lower anterior region Click here to view. View at: Publisher Site Amloodipine Scholar. J Clin Periodontol ; 19 : — He was advised on surgical periodontal treatment for aesthetic reasons and functional problems since the enlargement had not shown any significant changes after professional debridement with scaling hyperplwsia root planning. After excluding other potential causes, we considered the diagnosis of amlodipine-induced massive gingival hypertrophy. Pradhan and P. Virchows Arch319 Dec Regression of nifedipine-induced gingival hyperplasia following gingival to a same class calcium channel blocker, isradipine. Revised : 01 May However, a serious and often overlooked side effect of this class of drugs affects some patients. Pharmacokinetics Several reports have implicated nifedipine more often than any other member of this class of drugs for inducing gingival enlargement. Cyclosporine enlargement usually have a more highly vascularized connective tissue with foci of chronic inflammatory cells, particularly plasma cells, 20 plus presence of an abundant amorphous extracellular substance. J Periodontol amodipine View at: Google Scholar M. Take 1 capsule by mouth twice daily The hyperplasia of drug induced gingival overgrowth. Amlodipine-induced gingival hyperplasia. Tal, and D. On clinical examination a generalized and firm overgrowth of the gingival throughout the maxilla and hyperplaeia mandible were evident. Open in a separate window. Indexing amlodipine. Amlodipine-induced gingival enlargement is comparatively less prevalent among calcium channel blockers. Medically induced gingival hyperplasia. There are also case reports on gingival overgrowth associated with erythromycin and trimethoprim sulphamethoxazole. Amlodipine induced gum hypertrophy—a gingival case report.
E—E, The mechanism through which these medications trigger a connective tissue response is still poorly understood. Although CCBs do not directly affect the underlying alveolar bone, the gingival enlargement amlodipine increase accumulation of bacterial biofilm and prevent adequate oral hygiene measures, thus inducing inflammation, periodontitis, bone and tooth loss, and halitosis. Section stained with H and E revealed the presence of hyperplastic squamous epithelium without any dysplastic features. J Clin Periodontol ; 19 : — Whether these lesions are preventable by professional toothcleaning and installation of good oral hygiene habits before prescribing this class of drug is unknown and hyperplasia clinical trials. Calcium channel blockers are considered as potential etiological agent for inducing gingival enlargement. Prisant LM, Herman W. As amlodipine is a commonly prescribed hypertension drug in family practice, every physician should be aware of this usually overlooked but potentially harmful side effect, particularly if gingival oral symptoms arise during drug use. International Journal of Oral Science
On general examination, the patient was moderately built and nourished. Gingival suggests that the lesion is a consequence of the interaction between gingival fibroblasts, cellular and biochemical mediators of inflammation and drug metabolites 15 The management of drug-induced gingival overgrowth. J Periodont Res ; 25 1 : 25— Issue Date : January Share this article Amlodipine with email Share with twitter Share with linkedin Share with facebook. Amlodopine regimen change is not an option, the lesions should be hyperplasia with or without surgical intervention. Followup visit Patient was recalled ajlodipine every 3 months, amlodipine gingival hyperplasia. Prevalence of Amlodipine-related gingival hyperplasia. Amlodipine-induced gingival overgrowth. Gingival hypertrophy is an often overlooked but potentially harmful side effect of treatment with amlodipine and other calcium channel blockers. The underlying mechanism behind drug-induced gingival hyperplasia involves inflammatory and noninflammatory pathways. Patients must be informed of the tendency of certain drugs to cause gingival enlargement and the associated oral changes and the importance of effective oral hygiene. A amlodupine review of current concepts.
Fatt P, Katz B. Gingiival CCBs are important components of managing patient populations with hypertension, angina or supraventricular cardiac arrhythmias. Skip to main content. The lack of gingival inflammation and purulent discharge were other features of the clinical scenario. In contrast, nifedipine is highly lipophilic and penetrates the cell membrane rather quickly. References 1 Fatt P, Katz B. Skip to main content. Patient was educated and motivated for maintenance of proper oral hygiene. The patient in the case presented had gingival hyperplasia as a result of managing his hypertension amlodipine amlodipine. J Indian Soc Periodontol. Prevalence of amlodipine-related gingival hyperplasia. J Oral Pathol Med. The lack of gingival inflammation and purulent discharge were other features of the hyperplasia scenario. Lasers in non-surgical periodontal therapy. Advanced search.
Remaining excess gingival was corrected by surgical periodontal treatment. The management of drug induced gingival overgrowth. Prevalence of amlodipine-related gingival hyperplasia. Amlodipine possible gingival and hyperplasia have been proposed over the years. Prevalence of amlodipine-related gingival hyperplasia. Med Hypotheses ; Competing interests. Figure 7: One-month postoperative photograph Click here to view. Ethics declarations Competing interests The authors declare no conflict of interest. Amlodipine induced gingival hyperplasia. Baldness reddit forhims Abstract Gingival enlargement is one of the side effects associated with certain drugs. Prevalence of gingival overgrowth induced by calcium channel blockers: A community-based study. Med Oral ; External link. Drugs associated with gingival overgrowth can be broadly categorized into three major groups according to their therapeutic actions, namely, anticonvulsants, immunosuppressants, and calcium channel blockers [ gingival4 ]. This generation had multiple hyperplasia effects, including tachycardia, facial amlodipine and, among others, gingival overgrowth. Amlodipine-induced gingival enlargement was diagnosed and managed by thorough scaling and root planning. Surgical intervention is the most effective treatment of drug-induced GO along with withdrawal or substitution of medication combined with meticulous oral hygiene, plaque control, and removal of local irritants. Figure 2, amlodipine gingival hyperplasia.
J Curr Res Sci Med amlodipine The histological and the clinical evidences were consistent with amlodipine-induced gingival hyperplasia. Amlodipine induced gingival overgrowth: a case report. Jorgensen MG. Treatment is generally targeted on drug substitution and effective control of local inflammatory factors such as plaque and calculus 12hyperplasia Risk factors Dental plague and oral hygiene level The oral bacterial biofilm is a common risk factor for all forms of inflammatory periodontal diseases and its presence exacerbates CCB-induced gingival enlargement. Case report of amlodipine induced gingival hyperplasia—late onset at a low dose. Copyright Material printed in the West Indian Medical Journal is igngival by amlodipine and may not be reproduced in whole or in part without the written permission of the Editor. Professional mechanical removal of the dental plaque and calculus, through scaling and root planing, has shown positive effects in reducing hyperplasia enlargement by eliminating its inflammatory component. Gingival hyperplasia: a side effect of nifedipine and diltiazem. Case 3 — a intraoral picture at first visit b two months after phase-1 therapy. It has hyperplasiaa been proposed that the susceptibility to pharmacologically gingival gingival gingival may be governed by existence of differential proportions of fibroblast subset in each amlodipins which exhibit a fibrogenic response to these medications. Sharma S, Sharma A. Das SJ, Olsen Gingivql. Los anticonvulsivos, bloqueadores antihipertensivos de los canales de calcio, y los inmunosupresores son las tres clases principales de medicamentos conocidos por su posibilidad de causar hiperplasia o hipertrofia gingival inducida por medicamentos. A female patient of 50 years reported with complaints of uyperplasia swelling and generalized sensitivity of teeth since 2 months.